Understanding the difference between stem and primary cells is critical for experimental design. Two research models — SH-SY5Y and HeLa cells — illustrate the divide between immortalized and stem-like lines.

Primary Cells

Primary cells offer physiological relevance but have limited lifespan and variability.

Stem-Like and Immortalized Lines

SH-SY5Y provide neuron-like differentiation potential, while immortalized HeLa cells offer unmatched robustness for mechanistic studies.